中文摘要：

丁醇在发酵培养基中的积累所产生的毒性问题是限制丁醇产量的重要因素,然而对于Clostridium acetobutylicum是如何适应丁醇胁迫,进而调节菌体生长和代谢的,目前尚缺乏系统研究,不能全面揭示C. acetobutylicum的丁醇耐受性机制。对丙酮丁醇梭菌丁醇耐受性有关的研究成果进行了综述,旨在深入理解菌株丁醇耐受性发生改变的相关分子基础。希望为进行微生物丁醇耐受性分子机制的改造、提高菌株的丁醇耐受性提供新的研究思路。

英文摘要：

The accumulation of butanol in fermentation medium is the major barrier for production of butanol. Currently, system research was lack for adaptation to butanol stress of Clostridium acetobutylicum. The biological mechanism on butanol tolerance is rather complex and remains largely unknown. Recent literatures were retrospectively analyzed to further understand the molecular mechanism of butanol tolerance, and will provide new research clues for modifying the molecular mechanism of butanol tolerance and/or enhanced butanol tolerance.