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调控miRNA成熟通路的相关基因多态性与四川汉族人群胃癌的相关性研究
  • ISSN号:1004-549X
  • 期刊名称:《中国输血杂志》
  • 时间:0
  • 分类:R542.22[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]四川大学华西医院,四川成都610041
  • 相关基金:国家自然科学基金资助项目(81101326)
中文摘要:

目的探讨血清C反应蛋白(CRP)和心肌肌钙蛋白T(cTnT)在诊治急性心肌梗死(AMI)患者中的临床应用价值和意义。方法选择67例AMI患者(观察组)、51例非心血管疾病患者(对照组)及健康体检人群56例(健康对照组),分别测定CRP和cTnT水平并进行比较。结果观察组CRP及cTnT检测阳性率分别为82%和84%。对照组分别为6%和0,健康对照组分别为5%和0,观察组与对照组和健康对照组比较有显著性差异(P均〈0.01),对照组与健康对照组比较无显著性差异(P〉0.05)。观察组cTnT与CRP水平显著正相关(r=0.982,P〈0.01)。观察组CRP、cTnT单独检测时,其敏感度、特异度分别为82%,90%和84%,100%;联合应用两者后其敏感度为88%,特异度91%。结论cTnl与CRP对AMI的诊断及早期诊断具有重要的临床应用价值,值得临床推广应用。

英文摘要:

Objective It is to approach the clinical application Values and meaning of cardiac troponin T (cTnT) and C - reactive protein (CRP) in patients with acute myocardial infarction (AMI). Methods The plasma cTnT and CRP were detected and compared in 67 patients with AMI (observation group), 51 patients excluding cardiovascular diseases (control group) and 56 healthy people (healthy control group). Results The positive rate of cTnT and CRP was 82% and 84% in observation group, 6% and 0 in control group, 5% and 0 in healthy control group. There was significant difference between observation group and control group or healthy control group ( all P 〈 0. 01 ) , there was no significant difference between control group and healthy control group ( P 〉 0.05 ). There was significant positive correlation between cTnT and CRP in observation group ( r = 0. 982, P 〈 0.01 ). For the separate test of cTnT and CRP in observation group, sensitivity were 82% and 90% respectively, specificity were 84% and 100% respectively. The specificity and sensitivity of the two combined application were 91% and 88% respectively. Conclusion The detections of cTnT and CRP have very important clinical value in diagnosis and early diag- nosis of AMI, it is worth for clinical use application.

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期刊信息
  • 《中国输血杂志》
  • 中国科技核心期刊
  • 主管单位:中华人民共和国卫生部
  • 主办单位:中国输血协会 中国医学科学院输血研究所
  • 主编:刘忠
  • 地址:成都市东三环路二段龙潭总部经济城华彩路26号
  • 邮编:610052
  • 邮箱:cjbt@mail.sc.cninfo.net
  • 电话:028-61648584
  • 国际标准刊号:ISSN:1004-549X
  • 国内统一刊号:ISSN:51-1394/R
  • 邮发代号:62-186
  • 获奖情况:
  • 中文临床医学、特种医学类核心期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:21843