中文摘要：

循环肿瘤细胞（circulating tumor cell,CTC）是从肿瘤病灶脱落后进入血液循环的肿瘤细胞,在肿瘤的微转移检测、病情评估、疗效及预后评判等方面具有重要价值,但因其在血液中数量极少,难以检测,临床应用进展缓慢。近年来,随着生物学技术的不断发展,CTC的富集及检测新方法不断进步,其中基于核酸适配子的富集及检测方法不但能快速高效捕获和无损释放CTC,还能定性、定量分析CTC,甚至能检测出血液中的单个CTC和不同亚群的肿瘤细胞,具有良好的应用前景。

英文摘要：

Circulating tumor cells （CTCs） are cancer cells shed from tumor into blood circulation. These cells are valuable in micrometastatic detection, disease assessment, and therapy and prognosis prediction of tumors. However, the clinical application of CTCs progresses slowly due to its rarity in the blood and difficulty for detection. Given the development of biological techniques, scholars have developed several new methods for enrichment and detection of CTCs. Aptamer-based method shows a good prospect in CTC application. In this method, CTCs can be rapidly and efficiently captured, nondestructively released, and qualitatively and quantitatively analyzed. This method can also be used to detect single and sub-groups of CTCs.