中文摘要：

目的：探讨载脂蛋白CⅠ（ApoC1）和维生素E结合蛋白（AFM）与肺结核患者脂质代谢的相关性。方法采用ELISA法检测ApoC1、AFM在31例肺结核患者（肺结核组）和26名正常人（正常对照组）血清中的含量，两组均空腹抽血检测总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A1、载脂蛋白B、脂蛋白A和视黄醇结合蛋白等指标，并分析肺结核组血清差异蛋白质与临床检测指标的相关性。结果肺结核组ApoC1含量为（34.60±4.60）μg/mL，显著低于对照组的（38.43±5.12）μg/mL （t=2.703，P〈0.01）；肺结核组AFM含量为（15.69±6.79）μg/mL，高于对照组的（11.95±6.36）μg/mL（t=2.054，P〈0.05），且AFM 与患者的甘油三酯含量存在负相关性（rs=-0.371，P〈0.05）；ApoC1与所有临床指标均无相关性。结论 ApoC1和AFM可能参与了肺结核患者的脂质代谢。

英文摘要：

Objective To explore the relevance between lipid metabolism and the proteins of apolipoprotein C-Ⅰ （ApoC1） and vitamin E-binding protein （AFM） in TB patients. Methods The concentration of ApoC1 and AFM in 31 TB cases and 26 healthy controls were detected by ELISA. Both groups received fasting hemospasia, and the clinical indexes including total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, ApoA1, ApoB, lipoprotein B and retinol binding protein （RBP） were detected. The correlations of the proteins with clinical indexes in TB patients were also analyzed. Results The concentration of ApoC1 in TB cases was lower than that in healthy controls [（34.60±4.60）μg/mL vs（38.43±5.12）μg/mL, t=2.703, P〈0.01]. The concentration of AFM in TB cases was higher than that in healthy controls [（15.69±6.79） μg/mL vs （11.95±6.36）μg/mL, t=2.054, P〈0.05]. The concentration of AFM was negatively correlated with the serum level of TG （rs=-0.371, P〈0.05）. None of clinical indexes had correlation with APOC1. Conclusions ApoC1 and AFM may be associated with liqid metabolism in TB patients.