光学地活跃的 hydrobenzoins 是为生物学上活跃的建筑群,自然产品,和药品的混合物的进一步的推导的很重要的积木。在这份报纸,一条实际途径作为催化剂前与 Ru (OTf )(TsDPEN )(6 伞花烃) 为 benzils 的不对称的加氢被开发了在里面甲醇。因此,一系列 chiral hydrobenzoins 在好收益被综合与对中等 diastereoselectivities 好、对优秀 enantioselectivities 好。
Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been devel- oped for asymmetric hydrogenation of benzils with Ru(OTf)(TsDPEN)(rl6-cymene) as a pre-catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to moderate diastereoselectiv- ities and good to excellent enantioselectivities.