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Stereoselective Synthesis of Optically Active Hydrobenzoins via Asymmetric Hydrogenation of Benzils with Ru(OTf)(TsDPEN)(η6-cymene) as the Pre-catalyst
  • ISSN号:1001-604X
  • 期刊名称:《中国化学:英文版》
  • 分类:TQ453.4[化学工程—农药化工] TQ426.94
  • 作者机构:[1]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Jiangsu 215123, China
  • 相关基金:Acknowledgement We are grateful for financial support from the Na- tional Natural Science Foundation of China (NSFC) (21072145), the Foundation for the Authors of National Excellent Doctoral Dissertations of PR China (200931), and the Natural Science Foundation of Jiangsu Province of China (BK2009115). This project was also funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
中文摘要:

光学地活跃的 hydrobenzoins 是为生物学上活跃的建筑群,自然产品,和药品的混合物的进一步的推导的很重要的积木。在这份报纸,一条实际途径作为催化剂前与 Ru (OTf )(TsDPEN )(6 伞花烃) 为 benzils 的不对称的加氢被开发了在里面甲醇。因此,一系列 chiral hydrobenzoins 在好收益被综合与对中等 diastereoselectivities 好、对优秀 enantioselectivities 好。

英文摘要:

Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been devel- oped for asymmetric hydrogenation of benzils with Ru(OTf)(TsDPEN)(rl6-cymene) as a pre-catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to moderate diastereoselectiv- ities and good to excellent enantioselectivities.

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期刊信息
  • 《中国化学:英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编:
  • 地址:上海市枫林路354号中科院上海有机化学研究所
  • 邮编:200032
  • 邮箱:
  • 电话:021-54925243
  • 国际标准刊号:ISSN:1001-604X
  • 国内统一刊号:ISSN:31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,美国科学引文索引(扩展库),日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175