中文摘要：

目的合成具有抗肿瘤活性的毛叶假鹰爪素C的B环衍生物。方法以2，4，6-三羟基苯乙酮为原料，经甲基化、0-甲基化、羟醛缩合3步反应制得目标产物，并以6个人肿瘤细胞株进行抗增殖活性评价。结果制备了14个目标化合物，其中9个为新化合物。经1H—NMR、13C—NMR，MS确证结构。结论初步活性研究表明，除li的目标化合物均具有一定程度的抗肿瘤活性，1h和ln活性优于毛叶假鹰爪素C，B环引入两个F原子对化合物抗肿瘤活性具有-定贡献。

英文摘要：

OBJECTIVE To synthesize desmosdumotin C derivatives on B-ring with antitumor activity. METHODS The target compounds were synthesized from 2,4,6-trihydroxyacetophenone via methylation, O-methylation and aldol reaction. Their antiproliferarive activities were tested against six human tumor cell lines. RESULTS Fourteen target compounds were synthesized, nine of which were new compounds. All of them were characterized using 1H-NMR, 13 C-NMR and MS. CONCLUSION Preliminary pharmacological test showed that all the title compounds except li exhibited potent antitumor activities,1h and 1n were better than desmosdumotin C in vitro. Introducing two fluoro atom on B-ring would benefit its activity against some tumor cells.