中文摘要：

采用Gadelle-Defaye法制备了全-6-氨基-β-环糊精[β-CD-（NH2）7]，并用＂Grafting-from＂接枝法得到不同分子量的星型结构β-环糊精-g-聚L-谷氨酸（β-CD-g-PLGA）.对β-CD-g-PLGA进行酰肼化改性后与醛基化海藻酸钠（ALG-CHO）通过席夫碱交联反应制备β-CD-g-PLGA/ALG水凝胶.研究了前驱体浓度以及β-CD-g-PLGA分子量对β-CD-g-PLGA/ALG水凝胶性能的影响，并以疏水性辛伐他汀（SIM）为模型药物，研究了水凝胶对SIM的控制释放行为.

英文摘要：

A Gadelle-Defaye method was used to synthesis per-6-amino-β-CD [β-CD-（ NH2）7]. Then, different molecular weighted starβ-CD-g-poly（L-glutamic acid）（β-CD-g-PLGA-ADH） was synthesised via ＂grafting-from＂ method. The hydrogel precursors,β-CD-g-PLGA-ADH and oxided alginate（ALG-CHO） were mixed to prepare β-CD-g-PLGA/ALG hydrogel. The effect of solid content and molecular weight of β-CD-g-PLGA on the properties of hydrogel was studied. Simvastatin （SIM） was used as a model drug, the drug loading and release behavior of β-CD-g-PLGA/ALG hydrogel were researched. The introduction of β-CD into hydrogel made it an effective SIM loading and sustained release system.