中文摘要：

microRNA（miRNA）是一类长度约为22nt的小分子非编码RNA,对基因表达进行转录后调控。基因调控网络由各种回路,如前馈和反馈回路组成。它通过将外界刺激整合成合适的输出信号,控制细胞从增殖到死亡几乎所有的生命活动。已知基因调控网络的失调与肿瘤的发生发展密切相关。新近的实验证据表明,miRNA广泛参与基因调控网络中的反馈和前馈回路。该文主要介绍miRNA在基因表达调控网络中的作用及其与肿瘤发生发展的关系。

英文摘要：

MicroRNAs （miRNAs） are a class of short （～22 nt）,regulatory non-coding RNAs that inhibit the expression of protein-coding genes through binding to the 3＇-untranslated region （3＇UTR） of target mRNAs. Gene regulatory networks,which are made up of basic subcircuits,such as feedback and feedforward loops,control a wide range of biological processes,including development,cell differentiation,proliferation and apoptosis. Deregulation of gene regulatory network is highly associated with tumorigenesis. Emerging evidences suggest that miRNAs act as critical motifs of feedback and feedforward loops. This review summarizes the recent advance in the research field of miRNA regulatory network and its association with tumorigenesis.