中文摘要：

以人宫颈癌细胞（HeLa细胞）为对象考察了富精氨酸多肽RRRRRRRR（R8）修饰的金-三氧化二铁壳核纳米粒子（R8-Fe2O3@Au NPs）对活细胞的光毒性.研究结果表明,内化后的R8-Fe2O3@Au NPs对活HeLa细胞无显著的细胞毒性,但在激光照射下则可导致HeLa细胞的凋亡,表现出很强的细胞光毒性.R8-Fe2O3@Au NPs的细胞光毒性与照射激光波长有关,并随细胞吞噬的R8-Fe2O3@Au NPs的量、光照强度和时间的增加而增强.

英文摘要：

he laser induced cellular cytotoxicity of rich arginine peptide RRRRRRRR （ Rs ） modified ferric oxide core gold shell nanoparticles（ R8-Fe2O3@Au NPs） was studied. Although R8-Fe2O3@Au NP has a low eytotoxicity, the viability of nanoparticles internalized HeLa cell can be decreased by laser irradiation. The experimental result indicates that the R8-Fe2O3@Au NPs have significant cellular phototoxicity under laser irradiation. In addition, the cellular phototoxieity of R8-Fe2O3@Au NPsis dependent on the wavelength of irradiation laser, and increased by the irradiating time and light intensity.