中文摘要：

血脑屏障上存在诸多受体和转运体，如转铁蛋白受体、低密度脂蛋白受体和己糖转运体等。采用其相应的配体或抗体修饰可构建脑靶向递药系统，有望提高脑组织的药物浓度。增强对脑部疾病的治疗效果，降低毒性作用及不良反应。此外，利用正负电荷的吸附介导和鼻腔给药也可能增加药物的脑内递送。

英文摘要：

Receptors and transporters such as transferrin receptor, low density lipoprotein receptor and glucose transporter are found expressed on the blood-brain barrier. Funetionalization of drug delivery systems with ligands or antibodies of these receptors or transporter can enable brain to enhance drug delivery, improve treatment efficiency and reduce adverse effects. Besides, brain drug delivery can also be facilitated via absorption-mediated transcytosis or following intranasal administration.