中文摘要：

目的：通过围产期腹腔注射地卓西平马来酸盐（dizocilpine maleate,MK-801）建立精神分裂症（schizophrenia,SZ）发育大鼠模型,探讨不同剂量帕潘立酮（paliperidone,Pal）治疗对SZ发育模型大鼠行为学的影响。方法：将32只出生后7 d（P7 d）的雄性SD仔鼠随机分为对照组、模型组、Pal低剂量组（0.03 mg/kg）、Pal高剂量组（0.3mg/kg）,每组8只。模型组、Pal低剂量组、Pal高剂量组仔鼠腹腔注射0.2 mg/kg MK-801,一天1次,连续注射15 d;对照组腹腔注射等体积生理盐水（NS）。P45 d Pal治疗组大鼠腹腔注射0.03mg/kg或0.3 mg/kg Pal溶液,对照组和模型组接受等体积NS注射,一天2次,持续15 d。P60 d测试各组大鼠自发活动、社会交往、前脉冲抑制（pre-pulse inhibition,PPI）和Morris水迷宫等行为学指标。结果：与对照组比较,SZ发育模型大鼠自发活动总路程显著延长（P〈0.01）、社会交往时间显著减少（P〈0.01）、PPI显著降低（P〈0.01）、逃避潜伏期显著延长（P〈0.01）、而在目标象限游泳时间显著缩短（P〈0.01）;不同剂量Pal重复处理可以不同程度改善MK-801诱导的行为学异常。结论：围产期MK-801重复处理可引起大鼠成年后自发活动增加、社交功能损害、PPI和空间学习记忆功能缺陷,Pal治疗可以不同程度改善MK-801诱导的上述行为损害。

英文摘要：

AIM： To explore the therapeutic effects of different doses of atypical antipsychotic Paliperidone（ Pal） on behavioral changes in model rat by establishing the development model of schizophrenia（ SZ） by intraperitoneal injection MK-801 in perinatal. METHODS： Thirty-two newborn SD male rats were randomly divided into control group,model group,low-dose Pal group,and high-dose Pal group. SD rats were intraperitoneally injected normal saline（ control group） or 0. 2 mg / kg Dizocilpine（ MK-801） solution（ model group,low-dose Pal group,and high-dose Pal group） at the 7th day after birth（ P7）,once a day for 15 days. At 45th（ P45）day,normal saline（ control group and model group）or 0. 03 mg / kg Pal solution（ low-dose Pal group） or0. 3 mg / kg Pal solution（ high-dose Pal group） were intraperitoneally injected,twice a day for 15 days.Behavior test was conducted from P60 days. RESULTS： Compared with the normal control group,the locomotor activity total distance of SZ developmental model rat was significantly longer（ P〈0. 01）,social interaction time,pre-pulse inhibition（ PPI） and time spend in object quadrant were significantly reduced（ P〈0. 01） while the escape latency significant increased（ P〈0. 01）. Different doses of Pal could improve the MK-801-induced behavioral changes in varying degrees. CONCLUSION： Repeated MK-801 injection in perinatal rats can cause spontaneous activity increase,social interaction dysfunction, PPI damage, spatial learning and memory damage in adult rats,which all can be improved by paliperidone.