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长链非编码RNA H19基因多态性与早发冠心病患者易感性研究
  • ISSN号:1007-4368
  • 期刊名称:《南京医科大学学报:自然科学版》
  • 时间:0
  • 分类:R540.45[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:黄冈市中心医院心内科,湖北黄冈438000
  • 相关基金:国家自然科学基金(81270255); 黄冈市科技局专项课题(20130115)
中文摘要:

目的:评价经食管超声心动图(TEE)法与肺动脉导管(PAC)法监测心脏容量负荷与心脏血流动力学指标的一致性。方法:选择在我院进行冠状动脉旁路移植手术的45例患者,术中分别采用TEE及PAC监测右室舒张末期容量(RVEDV)、右室收缩末期容量(RVESV)和右室射血分数(RVEF),比较两种方法监测数据的一致性。结果:与基础值比较,TEE和PAC法均显示,负荷后RVEDV[TEE:(38±6)ml比(51±9ml),PAC:(153±17)ml比(188±19)ml]、RVESV[TEE:(19±4)ml比(33±5)ml,PAC:(92±16)ml比(110±23)ml]均显著增加(P均〈0.01),RVEF均无显著差异(P〉0.05)。PAC与TEE法在治疗前监测的RVEDV、RVESV、RVEF结果均具有良好相关性,相关系数均在0.8以上(r=0.844、0.862、0.916,P均〈0.01),在治疗后监测的RVEDV、RVESV的相关系数显著降到0.6以下(r=0.552、0.579,P均〈0.05),RVEF的相关系数仍保持在0.8以上(r=0.892,P〈0.01)。结论:经食管超声心动图与肺动脉导管在临床监测中一致性较高,前者为非创伤性检查,便于临床采用。

英文摘要:

Objective: To evaluate the consistency of transesophageal echocardiography (TEE) and pulmonary artery catheter (PAC) method in monitoring cardiac volume load and cardiac hemodynamic indexes. Methods: A total of 45 patients undergoing coronary artery bypass grafting in our hospital were selected. The right ventricular end-dias- tolic volume (RVEDV), right ventricular end-systolic volume (RVESV) and right ventricular ejection fraction (RVEF) were monitored during surgery by TEE and PAC respectively. Consistency of monitored data was compared between two methods. Results: Both TEE and PAC indicated that compared with baseline level, after loading, there were significant rise in RVEDV [TEE: (38 ± 6) ml vs. (51 ± 9ml), PAC: (153 ± 17) ml vs. (188 ± 19) ml], RVESV [TEE: (19 ± 4) ml vs. (33± 5) ml, PAC: (92 ± 16) ml vs. (110 ± 23) ml], P〈0.01 all, but there was no significant change in RVEF, P〉0.05. Before therapy, RVEDV, RVESV and RVEF monitored by PAC and TEE showed significant positive correlation, and all relevant coefficients were 〉0.8 (r = 0. 844, 0. 862, 0. 916, P〈 0.01 all) ; after therapy, correlation of RVEDV and RVESV significantly reduced to 〈0.6 ( r = 0. 552, 0. 579, P〈 0. 05 both), but RVEF correlation remained 〉0.8 (r = 0. 892, P〈0.01). Conclusion: In clinical monitor, the con- sistency of TEE and PAC is high, the former is non-traumatic, and is more convenient for clinical use.

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期刊信息
  • 《南京医科大学学报:自然科学版》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:南京医科大学
  • 主编:沈洪兵
  • 地址:南京市龙眠大道101号
  • 邮编:211166
  • 邮箱:nyxb@njmu.edu.cn
  • 电话:025-86869293 86869297
  • 国际标准刊号:ISSN:1007-4368
  • 国内统一刊号:ISSN:32-1442/R
  • 邮发代号:28-61
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),波兰哥白尼索引,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:18896