报道了铜催化胺与1,3-二羰基化合物的缩合反应.在CuCl催化剂的存在下,胺与1,3-二羰基化合物的缩合反应,可在四氢呋喃溶剂中、室温条件下顺利进行,生成烯胺酮化合物,收率为75%~98%.合成了16种烯胺酮化合物3a~3p,其中,3p为未知化合物.
Copper-catalyzed condensation reaction of amines with 1,3-dicarbonyl compounds is described. The condensation reaction of amines with 1,3-dicarbonyl compounds proceeded smoothly in the presence of copper chloride (CuCI) catalyst at room temperature in tetrahydrofuran (THF) to produce enaminones in range of 75%-98% yields. Sixteen kinds of enami- nones 3a-3p were prepared, and the 3p is an unknown product.