中文摘要：

目的探讨YKL-40与颈动脉粥样硬化斑块稳定性的相关性。方法在社区人群中进行横断面调查,经统一问卷调查获得人口学、行为生活方式、疾病史、用药史等信息,经彩色超声诊断仪检查颈动脉斑块情况。根据责任斑块的彩色超声成像影像学特征分为稳定性斑块组和不稳定性斑块组,并采用酶联免疫吸附法检测YKL-40水平。按四分位数,将YKL-40浓度分为低水平组（〈17.96 ng/ml）,低-中水平组（17.96-33.40 ng/ml）,中-高水平组（33.40-61.59 ng/ml）,高水平组（≥61.59 ng/ml）。采用Logistic回归模型分析YKL-40与颈动脉斑块稳定性的相关性。结果本研究共纳入296例有颈动脉斑块的研究对象,其中男性116例（60.8%）,中位年龄69岁,YKL-40浓度中位数33.40 ng/ml（四分位数：17.96-61.59 ng/ml）。单因素Logistic回归分析结果显示,以低-中水平组为参照,高水平组颈动脉斑块不稳定性检出风险为3.257倍,差异有统计学意义;低水平组和中-高水平组风险都增加了1.836倍,差异无统计学意义。多因素Logistic回归分析发现,调整年龄、性别、高血压、糖尿病、冠心病既往史、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、同型半胱氨酸和超敏C反应蛋白等因素后,与低-中水平组相比,低水平组发生不稳定性斑块的风险是1.638（95%CI 0.580-4.627,P=0.351 3）,中-高水平组发生不稳定性斑块的风险是2.144（95%CI 0.786-5.851,P=0.136 3）,高水平组发生不稳定性斑块的风险是2.653（95%CI 1.002-7.023,P=0.049 6）。结论 YKL-40的水平可能与颈动脉粥样硬化斑块稳定性相关。

英文摘要：

Objective To evaluate the association of YKL-40 level with carotid atherosclerotic plaque stability. Methods In this cross-sectional study, participants were recruited from a community. Information including demographics, behavior and life style, disease history, medicine condition was collected by trained interviewers. The carotid plaques were examined by color ultrasonography. The par- ticipants were divided into stable plaque group and unstable plaque group according to the imaging features of color uhrasonography of the dominant plaque. Serum YKL-40 was examined by enzyme-linked immunosorbent assay. According to serum YKL-40 quartiles, subjects were stratified into four groups：low level group（ 〈 17.96 ng/ml） , low-intermediate level group （17.96 -33.40 ng/ml） , middle- high level group （ 33.40 - 61.59 ng/ml） , high level group （ ≥ 61.59 ng/ml ）. Logistic regression model was used to analyze the associa- tion of YKL-40 levels with carotid plaque stability. Results A total of 296 pariticipants with carotid plaques were included in this study,including 116 males（60.8% ）with an median age of 69 years, and median YKL-40 concentration of 33.40 ng/ml（ quartile： 17.96 -61.59 ng/ml）. Univariate Logistic regression analysis showed that the risk for the instability of carotid atherosclerotic plaque was 3. 257 times in high level group compared with low-intermediate level group（ P 〈 0.05 ） , and 1. 836 times in both low level group and low-intermediate level group（ P 〉 0.05 ）. Multivariate Logistic regression analysis showed that after adjusting for age, gender, past history of coronary heart disease, hypertension, diabetes, total cholesterol, triglycerides, low density lipoprotein cholesterol, high densitylipoprotein cholesterol,homocysteine and hypersensitive C-reactive protein, the odds ratio was 1.638 （95% CI 0.580 -4.627, P = 0.351 3）in low level group compared to low-intermediate level group, 2. 144 （95 % CI 0. 786 -5. 851, P = 0. 136 3 ） in middle-high level grou