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Synthesis of Novel Phosphorylated Daidzein Derivatives and ESI Investigation on Their Non-Covalent Complexes with Lysozyme
  • ISSN号:1001-604X
  • 期刊名称:《中国化学:英文版》
  • 时间:0
  • 分类:O641.4[理学—物理化学;理学—化学]
  • 作者机构:[1]Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China, [2]Anyang Normal University, Anyang, Henan 455002, China, [3]The Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China
  • 相关基金:Project supported by the National Natural Science Foundation of China (Nos. 20132020 and 20175026) and Henan Academic Foundation of Science and Technology.
中文摘要:

Daidzein (7,4-dihydroxyisoflavone ) 是由修改 Atherton-Todd 反应的 phosphorylated。五个目标产品的结构,被 X 光检查,红外, NMR 和 ESIMS 决定。Electrospray 电离结果证明在煤气的阶段,所有 phosphorylated daidzein 衍生物能与蛋白质溶解酵素形成非共有原子价建筑群,当非共有原子价建筑群没与溶解酵素在 daidzein 的混合答案被检测时。每非共有原子价建筑群的相对亲密关系根据它的不同分解孔电压被获得。

英文摘要:

Daidzein (7,4'-dihydroxyisoflavone) was phosphorylated by a modified Atherton-Todd reaction. The structures of the five target product, were determined by X-ray, IR, NMR and ESI-MS. Electrospray ionization results show that in the gas phase all the phosphorylated daidzein derivatives could form non-covalent complexes with the protein lysozyme, while non-covalent complexes were not detected in the mixed solution of daidzein with lysozyme. Relative affinity of every non-covalent complex was obtained according to its different decomposition orifice voltage.

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期刊信息
  • 《中国化学:英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编:
  • 地址:上海市枫林路354号中科院上海有机化学研究所
  • 邮编:200032
  • 邮箱:
  • 电话:021-54925243
  • 国际标准刊号:ISSN:1001-604X
  • 国内统一刊号:ISSN:31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,美国科学引文索引(扩展库),日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175