中文摘要：

目的调查新疆维吾尔族人血清瘦素水平与总体肥胖及腹型肥胖的关系。方法从新疆和田地区维吾尔族流行病学调查数据库中,随机选取776例个体,年龄30~70岁,男性248例,女性528例。比较不同血清瘦素水平之间体重指数（BMI）、腰围（WC）及代谢指标的差异,并分析瘦素水平与总体肥胖及腹型肥胖之间的关系。结果随着瘦素水平的递增,新疆维吾尔族人群的WC、BMI、血清甘油三酯（TG）水平及胰岛素抵抗指数（HOMA-IR）逐渐升高;Spearman相关分析结果显示,新疆维吾尔族男性的血清瘦素水平与BMI（r=0.45）、WC（r=0.42）、HOMA-IR（r=0.29）、TG（r=0.25）呈正相关（P〈0.001）,与年龄呈负相关（r=-0.16,P=0.013）;新疆维吾尔族女性的血清瘦素水平与BMI（r=0.50）、WC（r=0.45）、TG（r=0.18）及HOMA-IR（r=0.14）呈正相关（P〈0.001）,与年龄无相关性（P=0.09）。血清瘦素水平（中位数）在肥胖、超重、对照组中分别为1.8 ng/dl、1.1ng/dl、0.5 ng/dl（P〈0.05）,在腹型肥胖及对照组中分别为1.6 ng/dl、0.7 ng/dl（P〈0.05）。结论新疆维吾尔族人的血清瘦素水平与BMI及WC均呈正相关;不论总体肥胖还是腹型肥胖者的血清瘦素水平均明显升高,并且这一变化趋势在女性中更为突出。

英文摘要：

Objective To investigate the Relationship between leptin and obesity in Xinjiang Uygurs. Methods A total of 776 individuals were selected randomly from the database of Hetian area in Xinjiang Uygur Autonomous Region, aging from 30 to 70 years,including 248 men and 528 women. Waist circumference（WC）, body mass index（BMI） and metabolic index among all cases with different levels of leptin were compared, and the relationship between leptin level and general obesity as well as central obesity were analysed.Results The levels of WC, BMI, triglyceride（TG） and HOMA- IR were increased along with the increasing leptin levels. According to Spearman analysis, leptin levels were positively correlated with BMI（r=0.45）, WC（r=0.42）, HOMA- IR（r=0.29）, TG（r=0.25）（P〈0.001）, and negatively correlated with age for male obese patients（r=- 0.16, P=0.013）. While for female obese patients, leptin were positively correlated with BMI（r=0.50）、WC（r=0.45）,TG（r=0.18）, HOMA- IR（r=0.14）（P0.001）,and uncorrelated with age（P=0.09.The median of leptin in general obesity, overweight and control group was 1.8 ng/dl, 1.1 ng/dl and 0.5 ng/dl, respectively（P〈0.05）. The median of leptin in central obesity and control group was 1.6 ng/dl and 0.7 ng/dl, respectively（P〈0.05）. Conclusion Leptin is positively correlated with BMI and WC, and is significantly elevated in both general obesity and central obesity, especially in women.