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急性脑梗死患者血浆同型半胱氨酸水平及其相关因素分析
  • ISSN号:1673-6273
  • 期刊名称:现代生物医学进展
  • 时间:0
  • 页码:5154-5159
  • 分类:R743.33[医药卫生—神经病学与精神病学;医药卫生—临床医学]
  • 作者机构:[1]同济大学附属第十人民医院神经内科,上海200072
  • 相关基金:国家自然科学基金资助项目(81171163);上海市科委重点资助课题(11411950303)
  • 相关项目:高同型半胱氨酸引起蛋白质硝基化的鉴定及机制研究
中文摘要:

目的:探讨急性脑梗死患者血浆同型半胱氨酸水平及相关因素。方法:采用高效液相色谱法检测232例急性脑梗死患者血浆Hcy水平,并对其相关因素进行统计学分析。结果:急性脑梗死组患者血浆Hey水平明显升高(P〈0.05);并与叶酸及维生素B12水平显著相关。不同年龄段急性脑梗死患者血浆Hcy水平具有差异。并与颈动脉粥样硬化斑块相关联。结论:血浆Hcy水平增高是脑梗死的危险因素之一,并与患者年龄、血液中叶酸、维生素B12水平及脑梗死性质相关联。

英文摘要:

Objective: To investigate the level of Homocysteine (Hey) in plasma of patients with acute cerebral infarction and the related factors. Methods: High Performance Liquid was used to test Homocysteine (Hey) in plasma of 232 patients with acute cerebral infarction. Relative factors were statistically analyzed. Results: The mean plasma level of Hey in patient group was obviously increased (P 〈0.05), and obviously interrelated with the level of serum folate and VitB12. Patients of different ages had different plasma levels of Hey. The results also showed that the plasma level of Hcy was significantly interrelated with atheroselerotic plaque. Conclusion: The increase of plasma level of Hey is a risk factor of cerebral infarction, and significantly interrelated with ages, the level of serum folate and VitB12 and the nature of acute cerebral infarction.

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期刊信息
  • 《现代生物医学进展》
  • 中国科技核心期刊
  • 主管单位:黑龙江省卫生厅
  • 主办单位:黑龙江省红十字医院 黑黑龙江省红十字医院 黑龙江省森林工总医院
  • 主编:申宝忠
  • 地址:哈尔滨市南岗区花园街184号403
  • 邮编:150001
  • 邮箱:biomed_54@126.com
  • 电话:0451-82583800 53658268
  • 国际标准刊号:ISSN:1673-6273
  • 国内统一刊号:ISSN:23-1544/R
  • 邮发代号:14-12
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:33230