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不同地区癌症发病分布特征及聚类分析
  • ISSN号:1007-3639
  • 期刊名称:中国癌症杂志
  • 时间:0
  • 页码:-
  • 分类:R73-31[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:[1]郑州大学公共卫生学院流行病与卫生统计学教研室,河南郑州450001, [2]郑州大学基础医学院组织学与胚胎学系,河南郑州450001, [3]焦作市人民医院护理部,河南焦作454150
  • 相关基金:国家自然科学基金(81001280; 81202277; 81373096)
  • 相关项目:PRDM16基因甲基化与肥胖关系的分子流行病学研究
中文摘要:

背景与目的:癌症严重威胁人类健康和社会经济发展,是我国及全球主要的公共健康问题。该研究旨在探讨多种癌症在我国不同地区的分布特征及与癌症患病率之间的关系,为癌症预防和管理提供科学依据。方法:数据来源为2012年军事医学科学院出版的《中国癌症发病与死亡2003—2007》,收集全国32个地区的2003—2007年不同性别人群的23种癌症发病率资料,采用对应分析获得不同地区的癌症分布特征,采用聚类分析将相同特征的癌症与地区聚为一类,可获得多个有特殊意义的分类。结果:食管癌、胃癌、肝癌、肺癌和结直肠与肛门癌均是男、女性高发病种。所有分组资料的食管癌和胃癌高发区涉县、阳城县、林州市、盐亭县、扬中市和建湖县等地区常聚为一类;扶绥县属于多种癌症发病率低于全国平均水平而肝癌高发区,在男性和合计发病率资料中单独聚为一类;广州市、四会市和中山市属于男、女性鼻咽癌高发区;启东市和海门市等农村地区属于肝癌高发区,在合计和男性发病率资料中聚为一类;结直肠与肛门癌和女性乳腺癌聚为一类,属于城市地区高发病种;女性子宫颈癌属于发病率仅次于消化系统癌症、肺癌和乳腺癌的高发病种。结论:聚为同一类的食管癌高发区涉县、磁县和阳城县等地区和聚为同一类的其他地区或癌症可能存在共同的致癌因素。

英文摘要:

Background and purpose: Cancer is a major public health issue in China and worldwide, which seriously threatens human beings as well as social and economic development. This study explored the relationships between the cancer distribution characteristics and cancer prevalences in Chinese cancer surveillance regions to provide scientific evidence for cancer prevention and management. Methods: The data were obtained from the book named "Prevalence and Mortality of Cancer in China from 2003-2007" including incidence of 23 cancer types in 32 regions of China published by the Academy of Military Medical Sciences of the Chinese PLA in 2012. Correspondence analysis was used to gain the relation between the prevalence and area distribution. Cluster analysis was used to obtain the classifications with special significance by putting the cancers or regions with similar characteristics into a cluster. Results: Esophageal cancer, gastric cancer, liver cancer, lung cancer, colorectal and anal cancer have high incidence and mortality in both genders. The districts with high incidence of esophageal cancer and gastric cancer were grouped together. The counties or cities (Shexian, Yangcheng, Linzhou, Yanting, Yangzhong and Jianhu) with high incidence of esophageal cancer and gastric cancer were classified into same cluster frequently. Fusui was grouped along because of the lower incidence of various cancers than the national average except for liver cancer. Guangzhou, Sihui and Zbongshan were the districts with high incidence of nasopharyngeaJ carcinoma in both genders. Rural areas in Qidong and Haimen were classified into a vluster in male and Iolal dala for the high incidence of liver cancer. Colorectal eanver, anal eaneer and breast cancer in women also had high incidence in urban areas. Cervical cancer had the seeond level high incidence in women fnllowing diseases of digestive system, breast cancer and hmg cancer. Conclusion: Similar pathogenie fae, tors may exist in counties or cities of Shexian, Cixian, Yan

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期刊信息
  • 《中国癌症杂志》
  • 中国科技核心期刊
  • 主管单位:中华人民共和国教育部
  • 主办单位:复旦大学附属肿瘤医院
  • 主编:沈镇宙
  • 地址:上海市徐汇区东安路270号6号楼3楼
  • 邮编:200032
  • 邮箱:zgazzz@163.com
  • 电话:021-64188274 64175590-3574
  • 国际标准刊号:ISSN:1007-3639
  • 国内统一刊号:ISSN:31-1727/R
  • 邮发代号:4-575
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:19590