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小胶质细胞介导缺血性卒中后炎症的机制研究进展
  • ISSN号：1673-2642
  • 期刊名称：国际神经病学神经外科学杂志
  • 时间：2012
  • 页码：316-319
  • 分类：R742.5[医药卫生—神经病学与精神病学;医药卫生—临床医学]
  • 作者机构：[1]南京大学医学院附属鼓楼医院神经科,江苏省南京市210008
  • 相关基金：国家自然科学基金（81171085）; 国家自然科学青年基金（81100863）
  • 相关项目：Malibatol A 激活PPARgamma促进替代型小胶质细胞形成保护缺血性脑损伤
作者： 韩丽娟|徐运|
关键词： 缺血性卒中, 炎症反应, 小胶质细胞, 活化, 经典型活化, 替代性活化, 脑保护
中文摘要：

小胶质细胞是中枢神经系统固有免疫细胞,在维持脑组织局部微环境稳定中发挥重要作用,是介导缺血性卒中后炎症反应的主要细胞,过度激活会加重脑组织炎症损伤,抑制炎症反应是潜在的卒中治疗手段。然而小胶质细胞亦可发挥脑保护作用,抑制不当会干扰其保护作用。本文对其在缺血性卒中后的损伤和保护作用进行综述,阐明调控小胶质细胞活化状态是缺血性卒中有效的治疗方法。

同期刊论文项目
Malibatol A 激活PPARgamma促进替代型小胶质细胞形成保护缺血性脑损伤
期刊论文 52
hUC-MSCs调控缺血性卒中后神经元-小胶质细胞crosstalk的机制研究
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期刊信息
  • 《国际神经病学神经外科学杂志》
  • 北大核心期刊（2014版）
  • 主管单位:中华人民共和国教育部
  • 主办单位:中南大学 中南大学湘雅医院
  • 主编：肖波 崔丽英
  • 地址：湖南省长沙市湘雅路87号
  • 邮编：410008
  • 邮箱：jinn@vip.163.com
  • 电话：0731-4327401
  • 国际标准刊号：ISSN：1673-2642
  • 国内统一刊号：ISSN：43-1456/R
  • 邮发代号:42-11
  • 获奖情况:
  • 国内外数据库收录:
  • 中国中国科技核心期刊,中国北大核心期刊（2014版）
  • 被引量:4860