为研究正常人群血糖的变化规律,应用大量实测数据构建了人群血糖均值随年龄变化曲线,提出一种基于Heckman模型的血糖曲线选择性偏差校正方法,对血糖曲线进行了偏差分析及校正.根据偏差显著性系数(IMR)呈显著状态以及数据校正对方程的参数估计结果的优化,证实了选择性偏差的存在以及对其有效的校正;应用跟踪数据进行了曲线趋势变化的验证,校正后的曲线平均误差明显小于校正前的平均误差,表明校正方法及校正结果的有效性.
To understand the variation of blood glucose for normal population,a more accurate description of average glucose level changing with different age groups is needed.This paper describes the curves of time-variation average glucose using a great mass of measured data and the method to correct selective bias based on Heckman model is proposed.It is realized that Heckman model theory could be adopted to analyze and correct the bias of glucose curves.The existence of the bias and correction effectiveness is confirmed by the analysis of the significance state ratio of selective bias(IMR) and parameter estimation.The trend of curve shapes is verified with the aid of tracking data.The average error of bias-collected curve shapes of time-variation average glucose is significantly smaller than that without correction.The result shows the effectiveness of proposed correction method.