中文摘要：

异常的创伤愈合后发生的皮肤瘢痕形成以真皮成纤维细胞增殖和胶原的过多沉积为特征。MicroRNA（miRNA）是一类由18-25核苷酸组成的单链非编码RNA,参与调控瘢痕形成的多种机制,包括调控TGF-β/Smads信号通路、ECM合成与降解、FBs增殖与分化和上皮间质转化（EMT）。本文综述了miRNA参与调控瘢痕形成的基础和临床研究进展,以期深入了解皮肤瘢痕形成的机制。

英文摘要：

Skin scarring is abnormality of wound healing characterized by excessive proliferation of fibroblasts and production of collagen in skin dermal tissue. MicroRNA （miRNA） is a class of small oncoding RNAs, ranges from 18 to 25 nucleotides, plays important role in key skin scarring processes includingtransforming growth factor （TGF）-beta signaling, extracellular matrix （ECM） deposition, epithelial to mesenchymal transition （EMT） , and fibroblast proliferation and differentiation. Here, we reviewed the basic and chnical research progress in miRNA＇ role in skin hypertropic scarfing, in order to further understand the mechanism of skin scarring.