中文摘要：

目的测定雷公藤甲素及其氨基糖结合物的表观溶解度、表观油水分配系数和解离常数（pKaT）。方法采用平衡溶解度法、摇瓶法测定雷公藤甲素及其氨基糖结合物的表观溶解度和油水分配系数；采用分光光度指示剂法测定雷公藤甲素-氨基糖结合物的解离常数。结果雷公藤甲素的表观溶解度随pH的增加而增加，其表观油水分配系数随pH的增加而降低，但变化并不显著。雷公藤甲素-氨基葡萄糖结合物的表观油水分布系数随pH的增加而增加，在纯水中的表观溶解度为1．9325±0．1373g，pKaT=5．938±0．191。结论雷公藤甲素是一个难溶性的亲脂性化合物，而雷公藤甲素-氨基葡萄糖结合物是一个弱碱性的亲水性化合物。

英文摘要：

OBJECTIVE To determine the apparent solubility,oil/water partition coefficient （P）and dissociation constant（pKT ） of triptolide and triptolide - glucosamine conjugate. METHODS The miniaturized shake - flask solubility method was adopted to deter- mine the equilibrium solubility of triptolide andtriptolide - glucosarnine conjugate. And a shake flask method was established to deter- mine the P of tfiptolide and triptolide - glucosamine conjugate. The pKT of triptolide - glucosamine conjugate was measured according to Spectrophotometric indicator method. RESULTS With pH increased, the apparent solubility of triptolide also increased while its P showed a decreasing trend. As for triptolide - glucosamine conjugate, the P increased with the increasing pH. In addition, its apparent solubilityin water was 1. 9325 ±0. 1373 g and its pKT was 5. 938 ± 0. 191 in water. CONCLUSION Triptolide is a slightly soluble compound with lipophicity,while triptolide -glucosamine conjugate is a weak basic compound with high hydrophicity.