中文摘要：

1-磷酸鞘氨醇（sphingosine 1-phosphate，SIP）是细胞膜鞘磷脂的代谢产物之-，在多种恶性肿瘤形成、转化和进展过程中发挥重要作用，能够调节肿瘤细胞增殖、凋亡及血管的新生。SIP对恶性肿瘤的生物学行为因细胞类型及受体（sphingosine 1-phosphate receptor，S1PR）表达不同而不同，在结肠癌和卵巢癌细胞中S1P通过SIPR1／S1PR3促进肿瘤细胞的生长，而在黑素瘤细胞中则通过S1PR2抑制肿瘤细胞的生长，不同受体介导的下游信号通路也不尽相同。因此，本文就S1P对不同肿瘤细胞生物学行为的影响及通过不同受体所介导的信号通路作一综述。

英文摘要：

S1P （sphingosine 1-phosphate） is one of the metabolite products of membrane sphingomyelin, and it plays an important role in formation, transformation and progression of many malignant tumors as well as the regulation of cell proliferation, apoptosis and angiogenesis. Furthermore, S1P plays different roles in regulation of biological behaviors of malignant tumors depending on the types of the cells and S1PR （sphingosine 1-phosphate receptor）. For ovarian cancer and colon cancer, S1P improves the growth of tumors cells by S1PR1/S1PR3, but for malignant melanoma, it inhibits the cell growth by S1PR2. There is a difference in the downstream pathways mediated by difficult receptors. This review summarizes the advances in research on the roles of S1P in regulating biological behaviors of tumor cells and different signal pathways of S1P mediated by various receptors.