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中文摘要：
以3-芳基-5-溴甲基异噁唑（1）为原料，与相应的酚或胺类发生亲核取代反应，合成了一系列未见报道的3-芳基-5-芳氧甲基异噁唑衍生物和3-芳基-5-芳胺甲基（或苄胺甲基）异噁唑衍生物．化合物结构均经过^1HNMR，IR，MS，HRMS和元素分析鉴定．通过合成的3-芳基-5-芳氧甲基异噁唑（3）对4砌括crassivora的致死率来评价了该系列化合物的生物活性，其中3-（2-氰基苯基）-5-（2-氯苯氧甲基）异噁唑（3p）表现出了较好的生物活性．
英文摘要：
A new class of 3-aryl-5-aryloxymethylisoxazole derivatives and 3-aryl-5-arylaminomethyl （or 5-benzylamino- methyl） isoxazole derivatives were designed and efficiently synthesized by nucleophilic substitution reaction of 3-aryl-5-bro- momethylisoxazole （1） with the corresponding phenols or anilines （or benzyl amines）, respectively. All of the target com- pounds were characterized by 1H NMR, IR, MS and elemental analysis. Besides, a biological activity study was performed to evaluate the mortality of 3-aryl-5-aryloxy-methylisoxazoles （3） towards Aphis crassivora. Particularly, 3-（2-cyanophenyl）-5- （2-chrolophenoxymethyl）isoxazole （3p） demonstrated a moderate biological activity.
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