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Effects of repetitive transcranial magnetic stimulation on hypothalamic-pituitary-adrenal axis of patients with depression

ISSN号：1005-9903
期刊名称：《中国实验方剂学杂志》
时间：0
分类：Q189[生物学—神经生物学;生物学—普通生物学] Q4[生物学—生理学]
作者机构：[1]Department of Psychiatry & Neurology, Affiliated Lianyungang Hospital, Medical College of Xuzhou, Lianyungang 222002, China, [2]Laboratory of Eleetroencephalography, Affiliated Lianyungang Hospital, Medical College of Xuzhou, Lianyungang 222002, China, [3]Center of Laboratory Medicine, Affiliated Lianyungang Hospital, Medical College of Xuzhou, Lianyungang 222002, China
相关基金：Supported by the Social Development Guide Projects of Science and Technology Committee of Jiangsu Province in 2005 （BS2005629） and ＂The Six Major Expert Peaks＂ Projects of Jiangsu Provincial Government in 2006 [Surentong （2006） 174]

作者： He Mingli[1], Gu Zhengtian[1], Wang Xinyi[2], Tian Xiaoping[3]

关键词：经颅磁刺激, 肾上腺轴, 抑郁症, 下丘脑, 患者, 促肾上腺皮质激素, 垂体, 随机对照试验, Depression, Transcranial magnetic stimulation, Hypothalamic-pituitary-adrenal axis

中文摘要：

调查睡觉的效果的目的调制脑电图的重复 transcranial 磁性的刺激(SEM-rTMS ) 和在 hypothalamic-pituitary-adrenal (HPA ) 的活动的常规 rTMS (C-rTMS ) 在有消沉的病人的轴。在一个双窗帘的方法，使随机化的控制试用，与消沉诊断的 164 个病人与 SEM-rTMS (n=57 ) 被使随机化到治疗， C-rTMS (n=55 ) 或为 30 min 的假冒的 rTMS (n=52 ) 每天为 10 d。在治疗前后，促肾上腺皮质的荷尔蒙(ACTH ) 和皮质醇(CORT ) 的血浆集中被测量，并且 24 条款哈密尔顿消沉等级规模(HAMD-24 ) 被用于评价。HAMD-24 获得的结果和血浆 ACTH 和在治疗前的这些压抑的病人的 CORT 集中与正常控制组的那些显著地不同(P < 0.05 ) 。在 SEM-r TMS 组和常规 rTMS 组的 HAMD-24 分数和血浆 ACTH 和 CORT 集中显著地被减少(P < 0.05 ) 。在 HAMD-24 分数和血浆 ACTH 之间有重要积极关联(n=240， r=0.105， P=0.048 ) 并且 CORT 集中(n=240， r=0.126， P=0.023 ) 在有在治疗前后的消沉的病人。结论包括 SEM-rTMS， rTMS 的抗抑郁剂效果可能与它的减少的 HPA 轴活动有关。（这条小道被登记。没有：ChiCTR-TRC-00000465 ）

英文摘要：

Objective： To investigate the effects of sleep electroencephalogram-modulated repetitive transcranial magnetic stimulation （SEM-rTMS） and conventional rTMS （C-rTMS） on the activity of hypothalamic-pituitary-adrenal （HPA） axis in patients with depression. Methods： In a double-blind, randomized controlled trial, 164 patients diagnosed with depression were randomized to treatment with SEM-rTMS （n=57）, C-rTMS （n=55） or sham rTMS （n=52） for 30 rain every day for 10 d. Before and after treatment plasma concentrations of adrenocorticotropic hormone （ACTH） and cortisol （CORT） were measured, and the 24-item Hamilton Depression Rating Scale （HAMD-24） was used for assessment. Results： The HAMD-24 scores and plasma ACTH and CORT concentrations of these depressive patients before treatment were significantly different from those of the normal control group （P〈0.05）. The HAMD-24 scores and plasma ACTH and CORT concentrations in the SEM-rTMS group and conventional rTMS group were decreased significantly （P〈0.05）. There was a significant positive correlation between the HAMD-24 scores and plasma ACTH （n=240, r=0.105, P=0.048） and CORT concentrations （n-240, r=0.126, P=0.023） in the patients with depression before and after treatment. Conclusion： The antidepressant effect of rTMS, including SEM-rTMS, may be related to its decreasing HPA axis activity. （This trail was registered. No： ChiCTR-TRC-00000465）