中文摘要：

随着痴呆发病率的日渐升高,该病引起了越来越多的关注。痴呆已成为威胁人类,尤其是老龄人群健康的重要临床难题。血管性痴呆(vascular dementia,Va D)是仅次于阿尔茨海默病的痴呆常见类型之一,包括缺血性或出血性脑血管疾病或是心脏和循环障碍引起的低血流灌注所致的各种临床痴呆。Va D是有望预防和治疗的痴呆,因此是近年来的研究热点,本文对Va D的分子机制和遗传机制研究进展进行综述。

英文摘要：

With the increasing incidence of dementia, more and more attention has been given to this disease. It has already been a clinical difficult problem threatening the health of mankind, especially for the aged people. After Alzheimer’s disease, vascular dementia (VaD) is the second leading cause of senile dementia, including ischemic or hemorrhagic cerebrovascular diseases or a variety of clinical dementia due to low blood flow induced by heart and circulatory disorders. VaD is a promising disease for prevention and treatment, and it has been a hot topic in recent years. Therefore, this article summarizes the recent advances in molecular and genetic mechanism of VaD.