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中文摘要：
线粒体是一种高度动态的细胞器,通过融合和分裂两个相反的过程来维持正常的形态结构。在哺乳动物中,多种因素影响线粒体的融合-分裂的平衡,但现已明确,线粒体融合的主要调节因子为Mfn1/2、OPA1,介导线粒体分裂的主要调节因子为Drp1、Fis1。新近研究发现,线粒体融合-分裂平衡的紊乱将导致线粒体结构和在细胞内分布的异常,进而影响细胞和线粒体对钙离子信号的反应;同时,钙离子也可通过多种机制影响线粒体的形态结构与分布。
英文摘要：
Mitochondria are dynamic organelles and maintain their structure through two opposing processes of fusion and fission.In mammals,there are many factors which influence the equilibrium between mitochondrial fusion and fission.It has been known that mitochondrial fusion is controlled by mitochondria-shaping proteins,including the large GTPase mitofusins（Mfn1/2） and optic atrophy protein 1（OPA1）,whereas the protein Fis1 and dynamin-related protein 1（Drp1） are the key mediators of mitochondrial fission.Recent data revealed the relationship between mitochondrial fusion/fission and Ca2＋ signaling.Ca2＋ handling is controlled by the change of mitochondrial fission-fusion balance.On the other hand,intra-and near-mitochondrial Ca^2＋ signals can modify mitochondrial morphology and cellular distribution.
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