中文摘要：

建立了一种恒温高压氧药物稳定性加速试验方法,用这种方法可在较短的时间内求得药物氧化反应的动力学参数.以10%维生素C溶液为例,维生素C在有氧和无氧条件下均可降解,总的降解速率常数kt由两部分构成：kt=kan＋kae,kan为无氧降解速率常数,可表达为kan=Aan·exp（-Ea,an/RT）;;kae为有氧降解速率常数,可表达为kae=Aae·exp（-Ea,ae/RT）·po2.

英文摘要：

An isothermal experiment with high pressure oxygen was established. The stability of 10% vitamin C solution as a model drug was studied and the kinetics parameters were obtained in a short time with the newly established experimental method. Because vitamin C degrades in both anaerobic and aerobic conditions, the total rate constant kt can be expressed as： kt =kan＋kae, where kan and kac are the anaerobic and aerobic degradation rate constants, respectively. The kan can be expressed as kan=Aan·exp（-Ea,an/RT） according to Arrhenius equation, and the kae was found to be kae=Aac·exp（-Ea,ac/RT）·Po2 in our experiments.