经颅磁刺激技术与中医穴位刺激相结合的研究和应用,近年来已经取得一定进展,图论理论在脑科学研究领域中也进行一些探索,这些理论和技术的交叉与结合将为神经磁刺激技术的应用和脑科学的研究开启新的方向。利用互相关方法对磁刺激光明穴和假穴的脑电信号进行了两两通道间的线性时域关联特性分析,得出各通道间脑电数据的相关数量关系,并且以相关矩阵的形式表示,通过阈值大小的设定获取邻接矩阵,分别构建磁刺激光明穴与磁刺激假穴实验状态下脑电信号的脑功能网络图。结果发现,磁刺激光明穴的脑功能连接相比于磁刺激假穴的脑功能连接在枕叶(视觉联络区)、额叶区显著增多。利用基于图论的复杂网络理论,对所构建的脑功能网络特性参数进行参数比较和统计学分析。磁刺激光明穴使得脑功能网络发生变化,主要包括网络平均度增大、聚类系数增大、特征路径长度减小、全局效率和局部效率提高、小世界属性增强,并且这些差异经过统计学检验在均值差值上都有量化体现,通过统计检验发现磁刺激光明穴引起的脑功能网络参数的改变具有显著性差异(P〈0.05)。研究提示,磁刺激光明穴相比磁刺激假穴,可以提高脑功能网络的全局效率和局部效率,缩短信息传播路径,使各个脑区之间的信息传递更加高效,为磁刺激技术施加于穴位改善神经功能提供一定的理论依据。
Recently, the research and application on the combination of transcranial magnetic stimulation (TMS) and aeupoint stimulation by traditional Chinese medicine has made some progress, graph theory has also been explored in the field of brain research. The combination of these theories and techniques will bring outa new direction for the application of neural magnetic stimulation and research of brain science. In this paper, the linear time domain correlation analysis of EEG between two channels of the magnetic stimulation at Guangming point and the mock point were carried out, each channel of the diencephalon electric data related to the number and the form of correlation matrix was determined by setting the size threshold for obtaining adjacency matrix. The brain functional network was constructed by the signals of the two experimental states. Results showed that the brain function of the laser beam was significantly increased than that of the occipital lobe ( visual contact area) and the frontal area. Based on the graph theory, complex network theory was used to compare the parameters of the characteristic parameters of the brain function network. Magnetic acupuncture point laser madethe brain functional network changed, the average degree of network and clustering coefficient were increased, and the characteristic path length decreased; meanwhile, the global efficiency and local efficiencywere improved, the property of small world was enhanced, all of which were statistically different. This work provided a theoretical basis for the application of magnetic stimulation technology in improving the nerve function of acupoints.