中文摘要：

肾间质纤维化是以正常的肾间质和肾小管结构被大量聚集的细胞外基质所替代为特征的病理过程,是多数慢性肾脏疾病进展为终末期肾衰竭共同的病变过程,其病理变化主要由多种细胞因子和多条信号通路控制,是众多关键信号通路的交互影响与共同作用的结果。深入了解信号通路的相互作用对进一步揭示肾间质纤维化的分子机制有重要意义。现综述肾间质纤维化病理变化中关键的信号通路,以期为肾间质纤维化分子机制的研究提供参考。

英文摘要：

Renal interstitial fibrosis（RIF）is a pathological process characterized by a large accumulation of extracellular matrix replacing normal renal interstitium and renal tubular structure. Most of the chronic kidney diseases have a common pathological process when developing renal failure, and RIF is the end stage. It is regulated by various cytokines and multiple signaling pathways; the cross-talk between key signaling pathways and their joint action result in the final changes. Deeply understanding of the cross-talk between signaling pathways may have important implications for further revealing the molecular mechanism of RIF. This paper review the key signaling pathways in RIF, so as to provide reference for research of molecular mechanisms of RIF.