中文摘要：

为了探究乌贼墨多糖（sepia ink polysaccharides,SIPS）对小鼠卵巢氧化应激和免疫能力的影响,将60只KM雌性小鼠随机分为正常组、模型组、治疗1组、治疗2组、治疗3组、治疗4组等6组。腹腔注射环磷酰胺（cyclophoshamide,CP）造模,正常组注射生理盐水,口服灌胃SIPS或生理盐水,观测各组小鼠体重变化、器官指数、卵巢丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性变化。结果表明：每只灌胃80 mg/kg SIP为多糖最佳剂量,与模型组相比,80 mg/kg处理能显著降低卵巢MDA含量、提高SOD活性,提高卵巢指数、胸腺指数、脾脏指数,增强小鼠卵巢抗氧化能力及免疫力。

英文摘要：

To explore the effects of sepia ink polysaccharides （SIPS） on ovarian oxidative stress and immune ability of mice, 60 KM female mice were randomly divided into 6 groups： normal group （CON）, model group （CP）, treatment groups 1 to d （SIP＋CP：1-4）. Mice injury model was built by intraperitoneal injection of cyclophosphamide, mice of normal group were injected with saline. Mice were oral administration of SIPS or saline. Then the weight changes, organ index of mice and ovarian MDA content and SOD activity were detected. The results showed that, 80 mg/kg SIPS per mouse was the optimal dose. Compared with the model group, 80 mg/kg SIPS could significantly reduce the ovarian MDA content and significantly improve the ovarian SOD activity, improve the ovarian index, thymus index and spleen index, intensify anti-oxidative function in ovary and the body immunity of mice.