中文摘要：

单独使用LXR激动剂T0901317喂食小鼠能减缓动脉粥样硬化发展,但会造成严重的脂肪肝.与ERK1/2抑制剂组合使用治疗能有效防止动脉粥样硬化发展,同时降低了两种药物剂量减轻了副作用.为研究组合药物对身体免疫系统的影响,从蛋白激酶C入手开展实验.在小鼠单核巨噬细胞RAW264.7中,PKCε被T0901317诱导,并呈现一定时间和浓度依赖性,并且用ERK1/2抑制剂U0126处理腹膜巨噬细胞能够上调PKCε.用T0901317和U0126喂食小鼠10 d,研磨心肌后上样,PKCε均未被两种药物上调,因而可见两种药物对PKCε的诱导表达呈现组织和细胞差异性.

英文摘要：

Administration T0901317 to vere fatty liver. A combination of U0126 and mice can inhibit atherosclerosis development but cause se- T0901317 was potentially used to cure atherosclerosis and received the reduction not only of dosage but also atherosclerotic plaque. PKC~ is induced by T0901317 in RAW 264.7, a monocyte cell line, in a time and dose dependent manner while U0126 up-regulate PKC6 in peritoneal macrophage. Heart extraction from mice fed with T0901317 and U0126 （ 1 mg/100 g food） is loaded on SDS-PAGE and showed no significant change from control team. Both drugs present different induction of PKCε in cell and tissues.