中文摘要：

目的：观察临床诊室浓度的艾烟暴露12周对Wistar雄性大鼠血清生化肝、肾功能指标的影响。方法：应用全自动动式染毒柜,艾烟的浓度以遮光率SR表示。将Wistar雄性大鼠48只随机分成4个艾烟浓度梯度组（n=12）：对照组（C,SR 0%）、低浓度组（L,SR 0.4%）、中浓度组（M,SR 2%）、高浓度组（H SR 15%）,分别为无艾烟组,1×,3×,和9×临床浓度艾烟组。每天暴露200 min,5天/周,连续暴露12周。应用全自动生化分析仪检测大鼠血清中肝肾功能等相关指标。结果：艾烟暴露各组肝功能指标ALT、AST、ALP、TBIL等未见明显差异（P〉0.05）。中剂量组CHO和高剂量组CR升高（P〈0.05）,但该波动为生理范围内的波动,余肾功能指标Urea及血脂指标TG未见显著影响（P〉0.05）,未见显著改变。结论：临床诊室浓度的艾烟暴露未对雄性大鼠血清生化肝、肾功能指标产生毒性影响。

英文摘要：

Objective： To investigate the effects of the long- term intervention of moxa smoke on liver and kidney function in Wistar rats. Methods： An automatic dynamic exposure device was applied for whole- body mode exposure. The moxa smoke concentration was represented by shading rate（ SR： x %）. Forty- eight male Wister rats were randomly divided into 4 groups（ n =12/group） ： three moxa smoke groups according smoke concentrations（ L 0. 4%,M 2. 0% and H 15%） and one control group（ C）. Three moxa smoke groups were respectively 1,3 and 9 times the clinical concentration. The exposure was continued for 12weeks（ 200 min/d and 5 d/week）. After exposure,the clinical chemistry parameters were tested on an automatic biochemical analyzer. Results： Compared with C group,no statistically differences on the liver function were found in smoke- exposed groups（ P〉 0. 05）. While the CHO in M and CR in H increased significantly（ P 〈 0. 05）,and they were in the rats’ normal ranges. The other indicators for the kidney function and the blood lipid were not changed at all（ P 〉 0. 05）. Conclusion： The 12- week moxa smoke exposure induced no smoke- related toxicity on liver and kidney function in male wistar rats.