中文摘要：

目的探讨吸烟在结直肠癌患者的病情进展过程中的作用。方法选取行结直肠手术,并经病理学诊断为原发性结直肠癌的男性患者119例。根据是否有吸烟史术前分为吸烟组63例和非吸烟组56例;术后分为非吸烟组56例、术后继续吸烟组39例和术后戒烟组24例。结果术前吸烟组与非吸烟组癌胚抗原（CEA）及C反应蛋白（CRP）水平比较,差异均无统计学意义（P〉0.05）。术后继续吸烟组原位复发率、转移率及CEA水平较非吸烟组和术后戒烟组均明显升高,差异有统计学意义（P〈0.05）。术后继续吸烟组、术后戒烟组和非吸烟组患者1、2、3年生存率比较,差异均无统计学意义（P〉0.05）。结论吸烟在结直肠癌的发生发展中起到的作用主要体现在影响手术前后患者血清CEA水平及通过影响肿瘤患者术后的复发率及转移率,直接促使肿瘤发展。

英文摘要：

Objective To explore the impact of smoking on the development of colorectal neoplasms. Methods A total of 119 male colorectal neoplasm patients underwent operation and pathologic diagnosis in recent years in our hospital were enrolled.These patients were divided into the smoking group（63 cases） and the non-smoking group（56 cases） before operation and further divided into the keep-smoking group（39 cases）,the quit-smoking group（24 cases） and the non-smoking group（56 cases） after operation. Results Preoperative carcinoembryonic antigen（CEA） and C reactive protein（CRP） values showed no statistically significant difference between the smoking group and the non-smoking group（P0.05）.Local recurrence rate,metastasis rate,and CEA values were significantly higher in the keep-smoking group than in the non-smoking group and the quit-smoking group（P0.05）.Survival rates of one year,two years,and three years were not significantly different among the three groups after operation（P0.05）. Conclusion Smoking mainly affects CEA values before and after operation as well as local recurrence rate and metastasis rate during the pathogenesis and development of colorectal neoplasms.