中文摘要：

目的探讨干细胞表面标志物CD90和胰岛素样生长因子1受体（insulin—likegrowthfactor1receptor，IGFlR）在肝癌中的表达情况及其与原发性肝癌的关系。方法应用免疫组化S-P法检测36例原发性肝癌中CD90、IGFlR的表达，并以20例肝脏血管瘤患者的正常肝组织作对照。随访33例患者，Kaplan—Meier法对患者中位生存期和生存率进行分析。结果原发性肝癌组织CD90、IGFlR蛋白的阳性表达率分别为63．89％（23／36）、52．78％（19／36），显著高于正常肝组织（0／20）、5％（1／20），二者比较差异有统计学意义（P〈0．05）。CD90在UICC临床分期Ⅲ、Ⅳ期中阳性表达率（79．17％）比I～Ⅱ期（33．33％）明显增高（P〈0．05），低分化组阳性表达率（76．92％）比高中分化组（56．52％）明显增高（P〈0．05）。IGFlR在UICC临床分期Ⅲ、Ⅳ期的患者中阳性表达率（70．83％）比I～Ⅱ期（16．67％）明显增高（P〈0．05），低分化组阳性表达率（84．62％）比高分化组（37．38％）明显增高（P〈0．05）。CD90阳性表达和IGFIR阳性表达呈显著正相关（P〈0．05）。CD90阳性者术后中位生存期为85d，而阴性者术后中位生存期为505d（P〈0．05），IGFlR阳性者术后中位生存期为100d，而阴性者术后中位生存期为408d（P〈0．05）。结论CD90、IGFlR可能与肝癌的发生发展相关。

英文摘要：

Objective To investigate the expression of CD90, IGF1R in hepatocellular carcinoma. Methods CD90, IGF1R expression were detected by SP immunohistochemical staining in 36 cases of hepatocellular carcinoma, 20 cases of normal liver tissue biopsied from patients of chronic cholecystitis undergoing cholecystectomy. Results The positive rate of CD90 （63.89% , 23/36） , IGF1R （52. 78% , 19/36） in hepatocellular carcinoma significantly increased （P 〈 0. 05 ）; The positive rate of CD90 was higher in UICC III - IV stage group （79. 17% ） than in UICC stage I - II group （33.33%, P 〈0. 05） ; The positive rate of CDg0 was higher in low differentiated group （76. 92% ） than in well-differentiated group （56. 52% ,P 〈0. 05）. The positive rate of IGF1R was higher in UICC III- IV stage group （70. 83% ） than in UICC stage I -II group （ 16. 67% , P 〈 0. 05 ）. The positive rate of IGF1R was higher in low differentiated group （84. 62% ） than in well-differentiated group （37. 38%, P 〈 0. 05 ）. The expression of IGF1R was positively correlated with that of CD90（P 〈 0.05）. The median survival of CD90＋ patients （85 days） was shorter than CD90- patients （505 days） （P 〈 O. 05 ）. The median survival of IGF1R ^＋ patients （ 100 days） was shorter than IGF1 Rpatients （408 days, P 〈 0. 05 ）. Conclusions CD90 or IGF1R expression correlates positively with the progression of HCC.