中文摘要：

脂联素（Adiponection）是一种最丰富的由脂肪细胞分泌的脂肪因子。它约占总血浆蛋白0.05%。人脂联素基因位于染色体3 q27,轨迹与糖尿病和心血管疾病的易感性接近。人体内的脂联素由247个氨基酸组成,分子量为30KD。由氨基末端的分泌信号序列（aa 1-18）,一段特异序列（aa 19-41）,一组由22个氨基酸组成的胶原重复序列（aa 42-107）,一段球状序列（aa108-244）组成。1996年国外学者Scherer和Hu等从脂肪细胞分化克隆而发现。对人体的研究发现,脂联素水平能预示2型糖尿病和冠心病的发展,并在临床试验表现出抗糖尿病、抗动脉粥样和炎症的潜力。本文将对脂联素与胰岛素抵抗、2型糖尿病及炎症的相关研究进行综述。

英文摘要：

Adiponectin is one of the most abundant fat secreted by fat cells factor. It accounts for about 0.05% of the total plasma proteins. Human adiponectin gene is located on chromosome 3 q27, and susceptibility locus close to diabetes and cardiovascular disease. Adiponectin in humans by 247 amino acids, molecular weight of 30KD. Secretory signal sequence from the amino terminus （aa 1-18）, some specific sequence （aa19-41）, a group of 22 amino acids from the collagen repeats （aa 42-107）, some globular sequence （aa108-244） components. 1996 Scherer and foreign scholars from Hu et al discovered adipocyte differentiation clone. Research findings on the human body, adiponectin levels can predict the development of type Ⅱ diabetes and coronary heart disease, and clinical trials showed anti-diabetic, anti- atherogenic and inflammatory potential. This paper will adiponectin and insulin resistance, type 2 diabetes and inflammation related research were reviewed.