中文摘要：

目的分析成人隐匿性自身免疫性糖尿病（LADA）、1型糖尿病（T1DM）、2型糖尿病（T2DM）及健康人群血浆糖蛋白磷脂酶D（GPLD1）水平的差异,探讨GPLD1与LADA的关系。方法选取2011年8—12月广西医科大学第一附属医院来诊的符合条件的受试者分成LADA组、T1DM组、T2DM组,同时选取同期健康志愿者作为正常对照组（NC组）。检测并对比分析4组血浆GPLD1、谷氨酸脱羧酶抗体（GADA）、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、餐后2 h血糖（2 hPG）、空腹C肽（FCP）、餐后2 h C肽（2 hCP）水平,分析血浆GPLD1与其他临床指标之间的关系及其对LADA的早期诊断价值。结果 LADA组GPLD1水平为（197.0±33.3）μg/ml,高于T2DM组〔（180.3±36.2）μg/ml〕和NC组〔（178.1±33.3）μg/ml〕,差异有统计学意义（P〈0.05）。LADA组血浆GPLD1与FCP呈线性负相关（r=-0.80,P〈0.05）,与HbA1c、FPG、2 hPG呈线性正相关（r=0.45、0.62、0.35,P〈0.05）。以血浆GPLD1水平为因变量,以年龄、病程、HbA1c、FPG、2 hPG、FCP、2 hCP为自变量行多因素线性回归分析显示,仅FCP进入方程（P〈0.05）。ROC曲线显示,GPLD1对早期诊断LADA有一定的临床预测价值〔曲线下面积（AUC）=0.623,敏感度为76%〕。结论 LADA患者GPLD1水平较健康人群升高,GPLD1在发病机制上与LADA关系密切。血浆GPLD1检测方便,有望成为早期诊断LADA的临床指标。

英文摘要：

Objective To analyze the differences of plasma glycoprotein phospholipase D（GPLD1） levels in patients with latent autoimmune diabetes in adults（LADA）,type 1 diabetes（T1DM）,type 2 diabetes（T2DM）,and healthy people,to explore the relationship between GPLD1 and LADA.Methods The patients who visited this hospital from August to December 2011 were divided into groups LADA,T1DM,T2DM and control.The levels of GPLD1,glutamic acid decarboxylase antibody（GADA）,glycosylated hemoglobin（HbA1c）,fasting plasma glucose（FPG）,postprandial 2 h plasma glucose（2 hPG）,fasting C-peptide（FCP）,postprandial 2 h C peptide（2 hCP） were determined and compared in the 4 groups.The relationship of GPLD1 to other clinical indicators and the early diagnostic values of GPLD1 for LADA were analyzed.Results The GPLD1 level of group LADA was（197.0 ± 33.3） μg / ml,higher than that of groups T2DM 〔（180.3 ± 36.2） μg / ml〕and control 〔（178.1 ± 33.3） μg / ml〕,the difference was significant（P〈0.05）.GPLD1 was negatively correlated with FCP（r =-0.80,P〈0.05）,positively correlated with HbA1c,FPG,2 hPG（r =0.45,0.62,0.35,P〈0.05） in LADA group.Taking GPLD1 as dependent variable,age,duration,HbA1c,FPG,2 hPG,FCP,2 hCP as independent variables,multivariate regression analysis showed that FCP entered into the equation（P〈0.05）.ROC curve showed that GPLD1 was of some clinical predictive value in early LADA diagnosis（AUC = 0.623,sensitivity 76%）.Conclusion GPLD1 level of LADA patients is higher than that of healthy group and GPLD1 is closely related to LADA in pathogenesis.The detection of plasma GPLD1 is convenient,which is expected to be an clinical indicator for LADA early prediction.