中文摘要：

目的观察黑米花色苷提取物（AEBR）对果糖喂养大鼠胰岛素敏感性的影响,并从c-Jun氨基端激酶（JNK）活化程度的变化分析其作用机制。方法将48只SD大鼠分成4组,设置对照,向高果糖饲料中添加8周或4周的AEBR（5 g/kg饲料）,检测各组大鼠胰岛素敏感性、脂肪组织胰岛素信号转导和JNK的活化情况。结果AEBR能够预防和改善高果糖膳食引起的大鼠胰岛素抵抗,抑制其脂肪组织内JNK的活化,显著增加胰岛素刺激后胰岛素受体底物-1（IRS-1）的酪氨酸磷酸化和葡萄糖转运体-4（GLUT4）的易位（P〈0.05）。结论AEBR可能是通过抑制JNK的活化来改善果糖喂养大鼠的胰岛素敏感性。

英文摘要：

Objective To investigate the effects and possible mechanisms of anthocyanin extracted from black rice （AEBR） on insulin sensitivity in fructose - induced insulin resistant rats. Methods A total of 48 rats were randomly divided into 4 groups fed with different diets for 8 weeks. Compared with the control group, the impact of AEBR on insulin sensitivity and activation of c- Jun NI-L2 - terminal kinase （JNK） in fructosefed rats supplemented with or without 5 g/kg of AEBR was assessed. Results AEBR prevented and attenuated high - fructose - induced insulin resistance, reduced the activation of JNK and improved insulin transduction in adipose tissue of fructose - fed rats （P 〈 0.05）. Conclusion The improvement of insulin sensitivity by AEBR in fructose- fed rats is associated with the inhibition of JNK activation.