中文摘要：

目的：研究大豆异黄酮磺酸酯化学修饰物的理化性质,并预测其药代动力学性质。方法：建立高效液相色谱法进行药物的理化性质测试和体外水解动力学试验。结果：大豆苷元-7,4′-二苯磺酸酯（DBS1）和大豆苷元-7-苯磺酸酯（DBS2）的脂溶性与水溶性相对于原药大豆苷元（DZ）均有显著的提高,脂水分配系数分别为：3.57±0.75和1.97±0.45;水解反应半衰期分别为2.14 h和19.25 h。DBS1的水解反应中4′-的磺酸酯基更易断裂。结论：化合物DBS1和DBS2的脂溶性、水溶性、脂水分配系数、熔点、极性表面积等影响药物药代动力学的一些主要性质得以优化,预示这2个化合物可能有相对较好的过膜吸收性与转运分布特性,以及良好的口服生物利用度。

英文摘要：

Objective：To study the physical and chemical properties of the soybean isoflavone sulphonic acid esters,and predict their pharmacokinetics.Methods：The HPLC method for testing the physical and chemical properties and hydrolysis kinetics in vitro of drugs was developed.Results：The fat-soluble and water soluble of daidzein-7,4＇-methylene dibenzene sulfonate（DBS1） and daidzein-7-benzene sulfonate（DBS2） relative to the partent drug daidzein（DZ） has significantly improved.The lipid-water partition coefficient is 3.57±0.75 and 1.97±0.45 and the half-life of hydrolysis is 2.14 h and 19.25 h respectively.The 4＇-the sulfonic acid ester group of DBS1 easierly fracture in hydrolysis.Conclusion：Their properties,such as,fat-soluble,water-soluble,lipid-water partition coefficient,melting point,polar surface,etc,that influenced their pharmacokinetics has been optimized.It indicates that these two compounds may have a relatively good transmembrane absorbent and transshipment of distribution,and good oral bioavailability.