中文摘要：

柔红霉素是临床上常用的抗白血病药物，疗效显著但是存在明显的个体差异。如何更多了解可能引起柔红霉素耐药的因素，从而提高柔红霉素的疗效，降低耐药，及减少药物的副反应，是目前临床工作者关心的问题。本文综述了影响柔红霉素药代动力学和药效学的遗传因素，旨在为柔红霉素临床个体化给药提供一定的参考依据。

英文摘要：

ABSTRACT Daunorubicin is a clinical anti-leu-kemia drug. The effect is significant but there are significant individual differences. How to learn more about the factors that may cause daunorubicin resistant, thereby improving the ef ficacy of daunomycin, reducing resistance, and reducing the side effects of the drug, is a con cern of clinical worker. This article reviews thegenetic factors that affect daunorubicin pharma cokinetics and pharmacodynamics and provides some reference for daunorubicin individualized clinical administration .