中文摘要：

[目的]观察氡对小鼠肺组织线粒体转录因子A（TFAM）及核因子（NF）-κB表达的影响,为探讨氡致肺损伤的机制提供实验依据。[方法]20只健康雌性BALB/c小鼠随机分为对照组及3个染氡组,每组5只,染氡组氡暴露剂量分别为30、60、120工作水平月。末次染毒后1 h内处死小鼠,取肺组织进行HE染色以及TFAM和NF-κB p65免疫组化染色,Western blot检测肺组织中TFAM和NF-κB p65的蛋白表达。[结果]免疫组化结果显示,染氡后TFAM、NF-κB p65阳性细胞数显著增加,其中120工作水平月组的TFAM和NF-κB p65阳性细胞率[（0.521±0.081）%、（0.260±0.068）%]高于对照组[（0.093±0.011）%、（0.069±0.016）%,P〈0.05],Western blot结果显示其蛋白表达也显著上升。[结论]氡暴露小鼠肺组织中TFAM和NF-κB的表达上调,提示NF-κB的信号通路被激活。

英文摘要：

[Objective] To observe changes in expression of mitochondrial transcription factor A（TFAM） and nuclear factor kappa B（NF-κB） in mouse lung tissue induced by radon, so as to provide experimental evidence for understanding related mechanism. [Methods] Twenty healthy female BALB/c mice were randomly divided into one control group and three experimental groups with cumulative doses of radon at 30, 60, and 120 working level months（WLM）. All mice were sacrificed 1 h after last treatment. The lung tissues were stained with HE, and the expressions of TFAM and NF-κB p65 were detected by immunohistochemistry and Western blot. [Results] The immunohistochemistry results showed that the positive cell rates of TFAM and NF-κB p65 significantly increased after radon exposure, and the 120 WLM group presented higher positive cell rates of TFAM and NF-κB p65 [（0.521±0.081）%,（0.260±0.068）%] than the control group [（0.093±0.011）%,（0.069±0.016）%, P 0.05]. So did the expression of protein according to Western blot. [Conclusion] The elevated expressions of TFAM and NF-κB induced by radon indicate an activation of NF-κB signaling pathway.