中文摘要：

目的：观察复方贞术调脂胶囊（FTZ）对实验性动脉粥样硬化家兔脂质代谢的影响。方法：将50只家兔分为正常对照组、模型组、辛伐他汀阳性对照组及FTZ高、低剂量组,每组10只。采用高脂饮食法建立兔动脉粥样硬化（AS）模型,给药组在喂高脂饲料的同时每天给予相应的药物,连续喂养12 w。检测实验前、实验第4、8、12周的血脂水平,于实验末测定血清载脂蛋白水平、肝脏脂质含量以及主动脉内膜斑块面积比。结果：FTZ能显著降低AS家兔血清的TC、TG、LDL-C、ApoB水平（P〈0.05或P〈0.01）,升高HDL-C水平和ApoAⅠ/ApoB比值（P〈0.05）;各给药组肝脏组织中的TC、TG含量以及内膜斑块面积比显著低于模型组（P〈0.05或P〈0.01）。结论：FTZ能有效调节实验性动脉粥样硬化家兔的脂代谢异常,这可能是其抗动脉粥样硬化作用的主要机理。

英文摘要：

Objective：To observe the effect of Fufang Zhenzhu Tiaozhi Capsule（FTZ） on lipid metabolism in atherosclerotic rabbits.Methods：50 rabbits were divided into five groups：normal control group,model group,simvastatin group,the high-dose group and low-dose group of FTZ.The atherosclerotic model was established by feeding the rabbits with high fat diet.The medicine interfered groups were administrated with homologous medicine on the base of high fat diet.All the rabbits were fed for 12 weeks.The blood lipids levels were determined just before the experiment and at the forth,the eighth and the twelfth weekend of the experiment.At the end of the experiment,serum apolipoprotein levels,liver lipid contents and the area of atherosclerotic plaque were determined respectively.Results：Compared with model group,TC,TG,LDL-C and ApoB levels were significantly decreased in FTZ groups（P〈0.05 or P〈0.01）.The level of HDL-C and the ratio of ApoAⅠ/ApoB were raised significantly（P〈0.05）.The contents of TC、TG in liver tissue and the area percentage of atherosclerotic plaque were also markedly reduced（P〈0.05 or P〈0.01） in the FTZ groups.Conclusion：FTZ could efficiently regulate the abnormality of lipid metabolism in experimental atherosclerotic rabbits,and this maybe one mamechanisms of its antiatherogenic effect.