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生物高分子的单分子物理研究
  • ISSN号：1000-0542
  • 期刊名称：《物理学进展》
  • 时间：0
  • 分类：Q66[生物学—生物物理学]
  • 作者机构：[1]南京固体微结构物理国家重点实验室南京大学,南京210093
  • 相关基金：This work was supported by NNSFC （Nos.10904064, 10834002 and 11074115）, NBRPC （No.2007CB814800）, NSFJP （No. BK2009008） and NCET.
作者： 秦猛[1], 曹毅[1]
关键词： 单分子力谱, 原子力显微镜, 蛋白质, 多糖, 核酸, 生物材料, single molecule force spectroscopy, atomic force microscope, protein, polysaccharide nucleic acid： biomaterials
中文摘要：

许多生物大分子通过机械力来调控其结构与生物功能。它们能够产生，感应，传递利响应力学信号，并且做出相应的构象变化。单分子力谱被广泛地用于表征这些生物分了在其生理环境下的构象变化，从而研究机械力对结构和功能的调控作用。我们将在这一综述中，总结不同乍物人分子力谱与其结构之间的对应关系，和各种相互作用对生物大分子力学性能的贡献和调控。这些研究也使得基于原子力显微镜的单分子力谱成为一个多功能的研究工具，把传统的生物化学和生物物理拓展到单分子层面。

英文摘要：

Many biomacromolecules use mechanical force as a critical regulator for their structure and biological functions. They generate, sense, transduce and response to mechanical force through their conformational changes. Single molecule atomic force microscopy techniques have been widely used to study the conformation of individual biomacromolecules under force in their biological environment and provide essential information of the interplay of structure, function and force. In this review, we show that how the nanomechanical behaviours and function of biomacromolecules are directly linked to their struc- tures and intra-molecular interactions. Based on this knowledge, single molecule AFM has been rapidly evolved into a multifunctional analytical tool which brings traditional biochemistry and biophysics to the new era at the single molecule level.

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期刊信息
  • 《物理学进展》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国物理学会
  • 主编：邢定钰
  • 地址：南京市南京大学
  • 邮编：210093
  • 邮箱：wlxjz@nju.edu.cn
  • 电话：025-83592484
  • 国际标准刊号：ISSN：1000-0542
  • 国内统一刊号：ISSN：32-1127/O4
  • 邮发代号:28-55
  • 获奖情况:
  • 国内外数据库收录:
  • 美国数学评论（网络版）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:3182