中文摘要：

目的前期研究表明，硫磺熏蒸对菊花的化学成分具有显著影响，本实验在此基础上对硫熏前后菊花入肠吸收成分进行比较研究。方法采用肠囊外翻模型，并结合超高压液相色谱一四级杆飞行时间质谱（UPLC-QTof-MS）和HPLC技术研究硫磺熏蒸对菊花入肠吸收成分影响。结果采用UPLC-QTof-MS定性比较，结果发现，硫磺熏蒸导致菊花入肠吸收的成分种类减少，比例发生改变。菊花硫熏前后，肠吸收液中黄酮苷类及黄酮苷元类成分存在显著性差异，硫熏菊花肠液中黄酮苷类成分的种类明显减少。采用HPLC对差异较大的7种成分进行半定量比较。菊花硫熏后，肠吸收液中黄酮苷类成分含量明显降低，而黄酮苷元类成分虽然在硫熏后药材中的含量增加，但在肠吸收液中其含量并未见明显增加。结论菊花经过硫熏后导致药材中化学成分的组成及比例发生变化，从而影响其入肠吸收。

英文摘要：

OBJECTIVE In previous studies, it was found that sulfur fumigation had a destructive effect on chemical constituents of Chrysanthemum Flos. To explore the intestinal absorption of Chrysanthemum Flos after sulfur fumigated. METHODS The evened rat intestinal sacs were used, and the absorbed was analyzed constituents by UPLC-QTof-MS and HPLC. RESULTS For sulfur fumi- gated Chrysanthemum Flos, the contents of flavonoid glycosides were declined in intestinal absorption, while the contents of flavonoid aglycones were not obviously increased. CONCLUSION Sulphur fumigation lead to the changes of Chrysanthemum Flos, which af- fects its intestinal absorption.