中文摘要：

像纤维蛋白原的蛋白质 2 (fgl2 ) ，新奇 prothrombinase，涉及 microthrombosis。我们与导致 streptozocin 的类型在老鼠在有 microthromsis 的 glomerular 和 tubulointerstitial capillaries 和它的关联检验了 fgl2 表示 2 糖尿病的 nephropathy。我们的 RT-PCR 和 immunoblotting 分析证明 fgl2 mRNA 和蛋白质层次在星期 19 点在 glomeruli 和肾的 interstitia 的 microvascular endothelial 房间被增加并且变得显著地与糖尿病的 nephropathy 的发展提高了(P < 0.01 ) 。Fgl2 没在正常老鼠的肾的纸巾被表示。而且，直接重要的关联(r = 0.543， P < 0.01 ) 在肾的纸巾在 fgl2 表示和 microthrombotic capillaries 之间被发现。连接 immunosorbent 试金(ELISA ) 另外看了那传播的酶在有类型 2 糖尿病的老鼠的 TNF- 伪层次显著地被提高并且密切与 fgl2 表示相关(r = 0.871， P < 0.01 ) 。我们的结果建议 fgl2 可以激活肾的 microthrombosis，因此贡献 glomerular 高血压和肾的局部缺血。

英文摘要：

Fibrinogen-like protein 2 （fgl2）, a novel prothrombinase, is involved in microthrombosis. We examined fgl2 expression in the glomerular and tubulointerstitial capillaries and its correlation with microthromsis in rats with streptozocin-induced type 2 diabetic nephropathy. Our RT-PCR and immunoblotting analysis showed that fgl2 mRNA and protein levels were increased in microvascular endothelial cells of the glomeruli and renal interstitia at week 19 and became significantly elevated with the development of diabetic nephropathy （P 〈 0.01）. Fgl2 was not or only weakly expressed in the renal tissues of normal rats. Furthermore, a direct significant correlation （r = 0.543, P 〈 0.01） was found between fgl2 expression and microthrombotic capillaries in the renal tissues. Enzyme linked immunosorbent assays （ELISA） additionally showed that circulating TNF-α levels in rats with type 2 diabetes were significantly elevated and closely correlated with fgl2 expression （r = 0.871, P 〈 0.01）. Our results suggest that fgl2 may activate renal microthrombosis, thus contributing to glomerular hypertension and renal ischemia.