中文摘要：

肾纤维化是慢性肾脏疾病（CKD）发展到终末期肾衰竭的共同病理,主要表现为细胞外基质（ECM）的过度沉积。MicroRNAs（miRNAs）是一类微小非编码RNAs,通过抑制目的基因mRNAs转录后的表达而调控肾脏的生理功能及稳态。miR-29s通过调节ECM的合成与沉积以及上皮-间质转化（EMT）发挥抗纤维化作用,另外,miR-29s与多种炎症和促纤维化通路相互作用,其作为治疗肾纤维化的试剂或者靶点研究有着重要意义和广泛前景。本文中我们综述了最近有关miR-29s抗肾纤维化作用的研究成果。

英文摘要：

One of the histopathological features of Chronic kidney disease （CKD） is renal fibrosis which is accompanied by the deposition of extracellular matrix （ ECM）. MicroRNAs are short non-coding RNAs that regulate most of important processes about renal physiological functions and homeostatsis, miR-29s are involved in the pathogenesis of fibrosis by regulating ECM production and deposition, and epithelial-mesenchymal transition （EMT）. In this review, we describe interactions of miR-29s with multiple pro-fibrotic and inflammatory pathways and miR-vs as a promising therapeutic reagent or target for the treatment of renal fibrosis. We also review the mechanism of microRNA-29s associated with renal fibrosis.