中文摘要：

肝素结合表皮生长因子样生长因子（ heparin-binding epidermal growth factor-like growth factor, HB-EGF）是表皮生长因子（epidermal growth factor, EGF）家族中的一员，与肝素有强的亲和性，生物活性与EGF类似。HB-EGF与EGF家族的其他成员共同调节角质形成细胞（keratinocyte，Kc）的生长。HB-EGF可能在银屑病发病的早期及维持银屑病表皮角质形成细胞的增殖中起关键作用，维A酸可能通过某种机制来调节表皮HB-EGF的表达，从而抑制银屑病表皮增殖并诱导正常分化。现将HB-EGF的来源、功能及与银屑病的关系综述如下。

英文摘要：

Heparin-binding epidermal growth factor-like growth factor（HB-EGF） is a member of the EGF family, which possesses a strong propensity to bind heparin. Biological activation of HB-EGF is similar to that of EGF. HB-EGF and other members of EGF are involved in the regulation of keratinocyte growth. HB-EGF may play a key role in the early pathogenesis of psoriasis and the psoriatic keratinocyte growth. Retinoid acid may regulate the expression of HB-EGF in psoriatic epidermis by some mechanism, which inhibits proliferation of epidermis and induces normal differentiation. The origin, function of HB-EGF as well as the relation between HB-EGF and psoriasis are discussed.