中文摘要：

目的：综合评价人群PPARγ2基因Pro12→Ala多态性与2型糖尿病（T2DM）的关联性。方法：以T2DM组和正常对照组的各PPARγ基因型频数和等位基因频数分布的OR值为统计量,全面检索相关文献;应用Meta分析软件包Revman5.1,在基因分型水平上,对各研究的结果进行一致性检验和数据合并,并评估发表偏倚。结果：PPARγ2基因Pro12→Ala多态性基因型及等位基因的分布频率在T2DM组和对照组之间的差异均有统计学意义（P〈0.05）;基因型合并OR值为1.19,等位基因合并OR值为1.29。结论：PPARγ2基因Pro12→Ala多态性（Ala等位基因）与T2DM有关联。

英文摘要：

Objective：To evaluate the relationship between the Pro︿12-Ala substitution in PPARγ2 and type 2 diabetes mellitus. Methods：Odds ratios（OR） of the PronAla allele distribution in patients with type 2 diabetes mellitus against healthy controls were analysed. All the relevant studies were identified, poor qualified studies were excluded and the pub- lication bias was evaluated. The Meta - analysis software RevmanS. 1 was applied for investigating heterogeneity among individual studies and for summarizing all the studies. Results： There were significant associations of the distribution of the allele frequencies and the genetype frequencies in the case and control groups （ P 〈 0.05）. Their pooled odds ratios were 1.19,1.29. Conclusion ：The Ala allele of Pro︿12-Ala polymorphism in the PPARγ2 gene is associated with T2DM.