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线粒体运动及其相关的细胞骨架和蛋白
  • ISSN号：1000-6737
  • 期刊名称：《生物物理学报》
  • 时间：0
  • 分类：Q27[生物学—细胞生物学] Q71[生物学—分子生物学]
  • 作者机构：[1]中国科学院生物物理研究所,生物大分子国家重点实验室,北京100101, [2]南京大学匡亚明学院基础学科教学强化部,南京210093
  • 相关基金：基金项目：“973”计划项目（2011CB910301）,国家自然科学基金创新群体项目（31021062）,中国科学院知识创新工程重要方向项目（KSCX2-EW-J-3）
作者： 陈邵宏[1,2], 庞效云[1], 孙飞[1]
关键词： 线粒体运动, 神经细胞, 芽殖酵母, 细胞骨架, 马达蛋白, 衔接蛋白, Mitochondrial movement, Neuron, Budding yeast, Cytoskeleton, Motor, Adaptor
中文摘要：

线粒体是真核细胞中十分重要的细胞器，它密切影响着细胞能量的供应、钙离子浓度的稳态以及细胞凋亡等过程。因此，线粒体恰当的分布关乎细胞的功能和生存，这就涉及到线粒体的运动和固定。在极化细胞（如神经细胞和出芽的芽殖酵母）中，线粒体的运动与固定之间的平衡就显得更为重要。细胞骨架以及一些相关蛋白在线粒体运动过程中起着重要作用。本文对线粒体运动的要素，如骨架蛋白、马达蛋白、衔接蛋白和线粒体上的货物蛋白等进行了归纳，并对当前线粒体运动研究的进展进行了综述。

英文摘要：

Mitochondria are elementary organelles in eukaryotic cells, which have a significant function on the cell energy supply, the calcium homeostasis, cell apoptosis, etc. Therefore, the proper mitochondria distribution, involving mitochondria movement and stationary, is linked with cell＇s function and survival. The balance between mitochondria movement and stationary seems more crucial in polarized cells （i.e. neuron cells） and budding yeast. The cytoskeleton and related proteins play the crucial roles in the process of mitochondrial motility, and those indispensable elements such as microtubule, microfilament, motor proteins, adaptor proteins and cargo proteins in the mitochondrion, as well as the recent studies in this field will be discussed in this review.

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膜蛋白与蛋白质复合体的结构生物学研究
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期刊信息
  • 《生物物理学报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科协
  • 主办单位:中国生物物理学会
  • 主编：沈恂
  • 地址：北京朝阳区大屯路15号生物物理研究所内
  • 邮编：100101
  • 邮箱：acta@sun5.ibp.ac.cn
  • 电话：010-64888458
  • 国际标准刊号：ISSN：1000-6737
  • 国内统一刊号：ISSN：11-1992/Q
  • 邮发代号:
  • 获奖情况:
  • 二次获得中国科协优秀科技期刊奖
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:7189