中文摘要：

转化生长因子-β（transforming growth factor-β,TGF-β）在细胞的自我调控包括细胞增殖、分化、凋亡、胚胎发育、免疫监督、血管再生等过程中发挥重要作用。TGF-βⅢ型受体（TβRⅢ）是TGF-β超家族的辅助受体之一,TβRⅢ不仅能介导TGF-β超家族配体依赖的Smad经典通路,还可以介导非Smad依赖的信号通路,参与调控细胞的多种信号通路,在纤维化、肿瘤、心血管系统等疾病中发挥重要作用。该文就TβRⅢ参与的信号通路及其在纤维化疾病中的作用作一综述。

英文摘要：

Transforming growth factor β（ TGF-β） superfamily ligands play an important role in regulating cellular homeostasisincluding proliferation,differentiation,apoptosis,immune surveillance and angiogenesis. Type Ⅲ TGF-β receptor（ TβRⅢ）is considered to be the coreceptor of TGF-β superfamily. TβRⅢnot only has an effect on classical Smad signaling pathway,but also on non-Smad signaling pathway. TβRⅢ plays a crucial rolein fibrosis,tumor,cardiovascular diseases via mediating kinds of signaling pathways. This paper reviews TβRⅢ mediated signaling pathway and its role in fibrotic diseases.